Glutathione deficiency due to gamma-glutamylcysteine synthetase deficiency. An autosomal recessive disease that causes nonspherocytic hemolytic anemia. Extremely rare. Hemolytic anemia is usually not severe. Other findings include hyperreflexia, jaundice, icteric sclera, peripheral neuropathy, splenomegaly, ataxia, dysarthria, biliary calculus, and hepatomegaly. Laboratory results may also show reticulocytosis and elevated bilirubin. Prognosis is difficult to determine due to the condition's extreme rarity.