ContentsSynopsisCodesLook ForDiagnostic PearlsDifferential Diagnosis & PitfallsBest TestsManagement PearlsTherapyReferencesView all Images (39)
Giant cell tumor of bone
Print
Other Resources UpToDate PubMed

Giant cell tumor of bone

Print Images (39)
Contributors: Eric Ingerowski MD, FAAP, Paritosh Prasad MD
Other Resources UpToDate PubMed

Synopsis

Giant cell tumor (GCT) of bone is a rare osteolytic tumor that typically arises in the skeletal bones of adolescents and young adults in their 20s, with a slight female predominance. While generally benign, its behavior is unpredictable. It is locally aggressive and most likely to occur at the epiphyses of long bones (femur, tibia). Less frequently, it can arise in the pelvis, vertebrae, and craniofacial bones. A small percentage of cases (1%-2%) may metastasize to the lung, but unlike a true metastatic malignancy, it has a favorable survival prognosis.

GCT of bone is characterized by localized pain, swelling, and limited range of motion.

Management traditionally relied on curettage and bone graft, but recurrence was as high as 50%. Improved aggressive curettage, high-speed burring, and use of adjuvants and bone cement have lowered the rate of recurrence. Various types of targeted therapies, surgery, radiation therapy, and chemotherapy are in use.

Codes

ICD10CM:
D48.0 – Neoplasm of uncertain behavior of bone and articular cartilage

SNOMEDCT:
697970009 – Giant cell tumor of bone

Look For

Subscription Required

Diagnostic Pearls

Subscription Required

Differential Diagnosis & Pitfalls

Best Tests

Subscription Required

Management Pearls

Subscription Required

Therapy

Subscription Required

References

Subscription Required

Last Reviewed: 02/09/2018
Last Updated: 04/19/2018
Copyright © 2019 VisualDx®. All rights reserved.
Giant cell tumor of bone
Print 39 Images
View all Images (39)
(with subscription)
Giant cell tumor of bone : Decreased range of motion, Lytic bone lesions
Copyright © 2019 VisualDx®. All rights reserved.