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Glomeruloid hemangioma - Skin
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Glomeruloid hemangioma - Skin

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Contributors: Belinda Tan MD, PhD, Jeffrey D. Bernhard MD, Noah Craft MD, PhD, Lindy P. Fox MD, Lowell A. Goldsmith MD, MPH, Michael D. Tharp MD
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Synopsis

Glomeruloid hemangiomas (GH) are acquired vascular lesions of the skin and other tissues that are frequently associated with POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes). POEMS syndrome is characterized by plasma cell proliferation with polyneuropathy, skin changes, Castleman disease, and various endocrinopathies. About 50% of patients with POEMS syndrome also have GH. Those typically affected are adults; there is no sex predilection.

The specific histopathological features of GH:
  • Discrete nodules composed of capillaries within a dilated vessel resembling renal glomeruli.
  • Occasional plump endothelial cells with eosinophilic PAS-positive, diastase-resistant globules representing immunoglobulins.
GH that are not associated with neoplastic diseases do occur, but their frequency is unknown. One patient was reported to have Sjögren syndrome and increased vascular endothelial growth factor (VEGF) expression but not POEMS syndrome.

Codes

ICD10CM:
D18.01 – Hemangioma of skin and subcutaneous tissue

SNOMEDCT:
403976007 – Glomeruloid hemangioma

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

GH are frequently associated with POEMS syndrome.

Best Tests

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Management Pearls

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Therapy

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References

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Last Updated: 10/31/2017
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Glomeruloid hemangioma - Skin
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Glomeruloid hemangioma : Trunk, Smooth papules, Multiple nodules, Red
Clinical image of Glomeruloid hemangioma
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