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Granuloma annulare in Infant/Neonate
See also in: External and Internal Eye
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Granuloma annulare in Infant/Neonate

See also in: External and Internal Eye
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Contributors: Lauren Strazzula MD, Vivian Wong MD, PhD, Susan Burgin MD, Craig N. Burkhart MD, Dean Morrell MD
Other Resources UpToDate PubMed

Synopsis

Granuloma annulare (GA) is a common inflammatory skin disorder of unknown etiology targeting the dermis or subcutaneous tissues. The disease is seen in children and adults and occurs most frequently in the first 3 decades of life. The condition is more common in girls than boys.

The disorder is usually localized when it occurs in children, but a generalized variant or a subcutaneous variant can occur.

GA may have a prolonged course, but lesions tend to spontaneously resolve without scarring.

Codes

ICD10CM:
L92.0 – Granuloma annulare

SNOMEDCT:
65508009 – Granuloma annulare

Look For

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

  • GA is most often mistaken for dermatophyte infection (tinea corporis, or "ringworm"). The presence of scaling in the annular plaques of a dermatophyte infection should allow the distinction. Additionally, dermatophyte infection can be diagnosed by KOH examination of associated scale.
  • Sarcoidosis can be annular and similar in appearance.
  • Subcutaneous GA is often mistaken for rheumatoid nodules or malignancy. Coexisting papular or annular lesions are frequently seen in patients with this form of GA.
  • Erythema annulare centrifugum may be distinguished from GA by characteristic trailing scale at the inner border of the annular erythema.
  • Lichen planus may occasionally present with annular lesions; however, these lesions tend to be flat-topped and violaceous with an overlying network of fine white lines (Wickham's striae).
  • Necrobiosis lipoidica presents as violaceous to red-brown plaques with atrophic yellow-brown centers on the shins.
  • Perforating GA or a papular form of GA can be mistaken for molluscum contagiosum.
  • Interstitial granulomatous dermatitis
  • Palisaded neutrophilic granulomatous dermatitis

Best Tests

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Management Pearls

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Therapy

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Updated: 05/25/2017
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Granuloma annulare in Infant/Neonate
See also in: External and Internal Eye
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Granuloma annulare : Ankle, Dorsum of foot, Dorsum of hand, Fingers, Smooth plaque, Smooth papules, Annular configuration, Lower legs
Clinical image of Granuloma annulare
Annular, orange-red, smooth plaque on the dorsal hand.
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