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Hibernoma - Skin
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Hibernoma - Skin

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Contributors: Gil Weintraub MD, Belinda Tan MD, PhD, Noah Craft MD, PhD, Lindy P. Fox MD, Lowell A. Goldsmith MD, MPH, Michael D. Tharp MD
Other Resources UpToDate PubMed


Hibernomas, or pseudolipomas, are rare benign soft tissue tumors derived from brown fat. The term hibernoma refers to the morphologic similarity of tumor cells to the brown adipose tissue (BAT) typically found in hibernating animals. BAT is present in newborns and is recognized as an important form of nonshivering thermogenesis in early life that significantly decreases in volume with age.

Hibernomas tend to present as painless slow-growing masses that are firm, mobile, and nontender to palpation. They are well-defined encapsulated hypervascular lesions that typically range in diameter from 5 to 10 cm but may grow to larger than 20 cm. Hibernomas are slightly more common in females and have a peak rate of incidence in the third decade of life, though cases have been documented across ages. There are 4 distinct pathologic variants of hibernomas: typical, myxoid, spindle cell, and lipoma-like. Each variant can be found intermuscularly, intramuscularly, or subcutaneously. Variants are not readily distinguishable clinically or on imaging and require histology for distinction.

Hibernomas are not considered life-threatening and only manifest symptoms secondary to compression of adjacent structures. While often slow growing and asymptomatic, patients may present with rapid tumor growth, fever, and weight loss. There are no reported cases of malignant transformation, recurrence, or metastatic spread after complete excision. Accurate preoperative diagnosis is critical in reducing patient anxiety and guiding proper surgical and surveillance strategy.


D17.9 – Benign lipomatous neoplasm, unspecified

77027006 – Hibernoma

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Differential Diagnosis & Pitfalls

Biopsy is necessary for identifying most of the differential diagnoses.
  • Lipoma – Benign slow-growing soft tissue tumor of white fat cells that often appears on the neck, trunk, extremities, and buttocks. Nontender, mobile, solitary or multiple, and usually occurs between the fourth and seventh decades of life.
  • Liposarcoma – Malignant tumor of fat cells with potential to grow very large.
  • Neurofibroma – These asymptomatic skin-colored or violaceous nodules can arise anywhere on the body, most commonly on the head, neck, and upper trunk. When compressed, the buttonhole sign is a strong diagnostic clue.  
  • Angiolipoma – These appear during the second and third decades of life as tender or painful subcutaneous swellings.
  • Lymphoma – Patients often present with systemic symptoms (fever, night sweats, weight loss, etc) in addition to a growing mass.
  • Rhabdomyoma – Benign tumor of striated muscle that occurs in children and adults.
  • Rhabdomyosarcoma – Rare malignant tumor most commonly found on the head, neck, genitourinary tract, and extremities. Typically occurs in younger children and is associated with bone destruction visible on imaging.

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Last Updated: 07/30/2014
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Hibernoma - Skin
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Hibernoma : Chronic duration lasting years, Tumor
Clinical image of Hibernoma
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