The spleen sequesters about one-third of blood platelets under normal circumstances, but with splenic enlargement, platelet sequestration may be as high as 90%. Splenic enlargement can occur at any age and can be transient (eg, underlying infection) or progressive.
Treatment involves managing the underlying condition leading to splenic enlargement, as splenectomy is rarely curative and should be reserved for select patients.
D73.1 – Hypersplenism
58381000 – Hypersplenism
- Drug-induced hemolysis (eg, antibiotics, NSAIDs, antimalarials)
- Splenic vein thrombosis
- Myeloproliferative disease
- Paroxysmal nocturnal hemoglobinuria
- Microangiopathic hemolytic anemia
- Thalassemia (alpha, beta)
- Myelodysplastic syndrome
- Infection (eg, malaria, mononucleosis, AIDS)
- Portal hypertension
- Thrombotic thrombocytopenic purpura / hemolytic uremic syndrome
- Idiopathic thrombocytopenic purpura
- Hereditary spherocytosis and other RBC membrane defects