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Idiopathic gestational thrombocytopenia
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Idiopathic gestational thrombocytopenia

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Contributors: Stefanie Hollenbach MD, Mitchell Linder MD
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Synopsis

Gestational thrombocytopenia (also called incidental thrombocytopenia of pregnancy or essential thrombocytopenia of pregnancy) is a common process identified in asymptomatic women in the second half of pregnancy.

Gestational thrombocytopenia is characterized by onset in the second or third trimester of isolated thrombocytopenia with steady (not precipitous) decrease in platelet count as the end of pregnancy approaches. This is most likely to be identified in the course of routine third trimester lab evaluation in as many as 5% of pregnant women.

While the platelet count is depressed in affected individuals, this does not increase maternal or neonatal risks for bleeding complications. This condition spontaneously resolves after delivery.

Codes

ICD10CM:
O99.89 – Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium

SNOMEDCT:
128090002 – Benign gestational thrombocytopenia

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

  • Primary immune thrombocytopenia – This disease may coincide with pregnancy including first notation during pregnancy. Especially consider if low platelets have been noted pregestationally. Antiplatelet assays exist but do not provide ability to differentiate from gestational thrombocytopenia. 
  • Preeclampsia spectrum disorders – More likely to demonstrate transaminitis, increased creatinine, and/or hypertension in addition to thrombocytopenia. 
Autoimmune-mediated processes:
Infectious etiologies:
Etiologies related to the effects of systemic illness on platelet number and function:
Isolated causes:

Best Tests

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Therapy

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References

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Last Reviewed: 08/14/2017
Last Updated: 08/15/2017
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Idiopathic gestational thrombocytopenia
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Idiopathic gestational thrombocytopenia : PLT decreased
Copyright © 2018 VisualDx®. All rights reserved.