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Kikuchi-Fujimoto disease
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Kikuchi-Fujimoto disease

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Contributors: Connie R. Shi, Susan Burgin MD
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Synopsis

Kikuchi-Fujimoto disease (KFD) is also known as Kikuchi disease or histiocytic necrotizing lymphadenitis. It is a rare condition presenting with fever, lymphadenopathy (typically cervical), and occasionally a rash on the face, upper extremities, or trunk.

The condition is most common in young adults (under age 30) of Japanese and other Asian descent, although cases in all ethnic groups have been reported. Children can also be affected.

The cause of KFD is not known. There have been proposed associations with viral infections such as Epstein-Barr virus (EBV). Associations between KFD and systemic lupus erythematosus (SLE) – with KFD sometimes preceding diagnosis of SLE – have also been reported.

KFD is self-limited and typically remits spontaneously in 1-4 months.

Codes

ICD10CM:
I88.1 – Chronic lymphadenitis, except mesenteric

SNOMEDCT:
127217009 – Histiocytic necrotizing lymphadenitis

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Last Reviewed: 02/01/2017
Last Updated: 03/30/2017
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Kikuchi-Fujimoto disease
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Kikuchi-Fujimoto disease : Cervical lymphadenopathy, Diarrhea, Fever, Nausea, Rash, Malaise
Clinical image of Kikuchi-Fujimoto disease
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