Clinical manifestations are related to chronicity of exposure.
- Acute exposure causes glucosuria, aminoaciduria, and renal phosphate wasting due to damage to the proximal tubules.
- Chronic exposure causes an elevated serum creatinine and hyperuricemia without significant proteinuria.
Treatment is elimination of further lead exposure. Chelation therapy can be considered, but studies of its effectiveness in treating lead nephropathy are not definitive.
N14.3 – Nephropathy induced by heavy metals
704204003 – Nephropathy induced by lead