Light-chain deposition disease
The proteinuria evident in light-chain deposition disease (LCDD) is mainly albumin, in contrast to myeloma cast nephropathy (with significant urinary light chain excretion).
LCDD is pathologically similar to amyloid light-chain (AL) amyloidosis, but the pathologic immunoglobulins do not form amyloid fibrils and do not stain Congo red. Serum and urine protein electrophoresis may not detect a monoclonal protein, but serum-free light chain analysis has increased sensitivity.
LCDD is most commonly associated with multiple myeloma but is also seen in patients with lymphoma or Waldenstrom macroglobulinemia. 30%-50% of cases are idiopathic. Treatment is geared towards controlling the plasma cell disorder.
N08 – Glomerular disorders in diseases classified elsewhere
373604002 – Light-Chain Deposition Disease