The onset of lobomycosis is insidious and progresses over decades. The incubation period is months to years. The fungus grows at temperatures less than 37°C, such that spread of the infection systemically does not occur. There is often a history of antecedent trauma and subsequent environmental exposure (often water).
There is a strong male predominance (approximately 90% of cases), probably related to occupational exposure (ie, agriculture).
There may be genetic factors increasing the risk of infection as certain Native American tribes of Brazil are frequently infected; however, specific genetic markers have not been identified. This disease is very rare in travelers, and the first case in an American traveler was reported in 2000.
B48.0 – Lobomycosis
47306003 – Lobomycosis
- Unlike the lesions of lobomycosis, the lesions of leprosy are hypopigmented and anesthetic.
- In mycetoma, sinus / fistula formation is seen, and expulsion of sulfur granules occurs.
- Unlike lobomycosis, patients with sporotrichosis may present with lymphadenopathy.
- Cutaneous tuberculosis
- Old World leishmaniasis
- New World leishmaniasis
- Mycobacterium marinum
- Squamous cell carcinoma (may be found concomitantly with lobomycosis)
- Tertiary syphilis