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ContentsSynopsisCodesLook ForDiagnostic PearlsDifferential Diagnosis & PitfallsBest TestsManagement PearlsTherapyDrug Reaction DataReferencesView all Images (29)
Longitudinal melanonychia - Nail and Distal Digit
See also in: Overview
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Other Resources UpToDate PubMed

Longitudinal melanonychia - Nail and Distal Digit

See also in: Overview
Print Images (29)
Contributors: William M. Lin MD, Susan Burgin MD, Shari Lipner MD, PhD
Other Resources UpToDate PubMed

Synopsis

Longitudinal melanonychia describes a longitudinal band of pigment that extends from the nail matrix to the free edge of the nail. Melanonychia means "black nail." There are many causes of nail pigmentation (see Differential Diagnosis section) including skin diseases, systemic diseases, infections, trauma, medications, and pigmented lesions. While longitudinal melanonychia can have a benign etiology, it is critical to rule out acral lentiginous melanoma as a cause.

Melanocytes normally reside in the nail matrix and nail bed, though they are typically inactive in individuals of Northern European descent. If melanin production in nail matrix melanocytes exceeds that which keratinocytes can degrade, this gives rise to a longitudinal band. This phenomenon can be caused by melanocyte activation, melanocytic hyperplasia, lentigo simplex, melanocytic nevus, atypical melanocytic proliferations, and acral lentiginous melanoma.

Pediatric nail melanoma is extremely rare, particularly in individuals with Fitzpatrick phototypes I and II, but carries significant morbidity and mortality. Evaluation of longitudinal melanonychia is more difficult in children than adults due to lack of clinical and histopathological guidelines.

Codes

ICD10CM:
L60.8 – Other nail disorders

SNOMEDCT:
402633003 – Melanonychia

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

Causes of longitudinal melanonychia include the following:
  • Subungual melanoma / acral lentiginous melanoma – Most melanomas of the nail appear in adulthood, with a mean age of onset in the 50s-70s. Nail pigmentation is the presenting sign in two-thirds of cases, though melanoma may present with a mass lesion, invariably accompanied by nail dystrophy and nail plate ulceration. Rarely, lesions are amelanotic. Hutchinson sign, periungual pigmentation indicating the radial growth of subungual melanoma, is frequently seen. The thumb and hallux are most frequently affected.
  • Longitudinal melanonychia is very common among those with deeper skin pigmentation, with as high as 77% of Americans of African descent over 20 and nearly 100% over 50 showing longitudinal melanonychia. Nails of digits prone to trauma or those used for grasping (thumb, index, and middle fingers) are frequently affected.
  • Congenital nevus / acquired nevus – Nevi cause approximately 12% of longitudinal melanonychia in adults and almost 50% of longitudinal melanonychia in children. Fingers are more commonly involved. Pseudo-Hutchinson sign (periungual pigmentation) is seen in one-third of cases.
  • Subungual lentigo
  • Chronic trauma-related injury (carpal tunnel syndrome, onychotillomania)
  • Medication-induced longitudinal melanonychia (eg, zidovudine [AZT] and hydroxyurea are both frequent causes of longitudinal pigment; minocycline, bleomycin, cyclophosphamide, and hydroxycarbamide have also been cited as causes of longitudinal melanonychia) (see drug-induced nail pigment)
  • Infection (onychomycosis)
  • Inflammatory skin diseases (psoriasis, lichen planus)
  • Connective tissue diseases (systemic lupus erythematosus, localized scleroderma)
  • Endocrine disorders (Addison disease, Cushing syndrome, Nelson syndrome, hyperthyroidism, acromegaly). Longitudinal melanonychia typically affects multiple fingernails and toenails. Individuals with Addison disease also show cutaneous and mucosal pigmentation.
  • Nutritional disorders and errors of metabolism (hyperbilirubinemia, alkaptonuria)
  • AIDS
  • Phototherapy, radiation (x-rays, electron beam therapy)
  • Genetic syndromes including Laugier-Hunziker syndrome or Peutz-Jeghers syndrome
Differential diagnosis of nail pigmentation:
  • Bacterial pigmentation, most commonly from Pseudomonas or Proteus, can have a greenish or grayish hue and is often located at the lateral edge of the nail.
  • Subungual hematoma is often the result of trauma and is most commonly found on the medial aspect of the first toe.
  • Exogenous nail pigmentation is most commonly caused by dirt, tobacco, potassium permanganate, and tar and typically does not cause a longitudinal streak. Most can easily be removed through physical means.

Best Tests

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Therapy

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Reviewed: 03/07/2017
Last Updated: 03/27/2017
Copyright © 2018 VisualDx®. All rights reserved.
Longitudinal melanonychia - Nail and Distal Digit
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Longitudinal melanonychia : Brown color, Longitudinal black nail bands, Scattered nails or distal digits, Solitary nail or digit
Clinical image of Longitudinal melanonychia
Copyright © 2018 VisualDx®. All rights reserved.