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Malignant mesothelioma
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Malignant mesothelioma

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Contributors: Mary Anne Morgan MD, Ryan R. Walsh MD, Joshua J. Jarvis MD, Alastair Moore MD
Other Resources UpToDate PubMed

Synopsis

Rare but aggressive malignancy of the mesothelial tissue (serosal membrane) of the pleura (most frequent type), peritoneum, pericardium, and tunica vaginalis, commonly associated with long-term occupational exposure to asbestos. Onset is gradual, typically years after exposure. Few symptoms manifest until advanced stages, unless discovered inadvertently during chest imaging. Characterized by chest pain, cough, dyspnea, anorexia, and fatigue. Other common signs and symptoms include abdominal pain, ascites, nail clubbing, and abdominal distension. Risk of lung cancer is greatly increased in smokers exposed to asbestos.

Management for stages I and II is typically surgical resection, followed by adjuvant therapy, radiation therapy, and/or chemotherapy. Treatment of nonsurgical candidates includes radiation therapy or combined modality therapy (chemotherapy and thoracic irradiation).

Codes

ICD10CM:
C45.9 – Mesothelioma, unspecified

SNOMEDCT:
115232000 – Mesothelial neoplasm

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Last Updated: 03/01/2016
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Malignant mesothelioma
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Malignant mesothelioma : Abdominal pain, Chest pain, Cough, Fatigue, Abdominal distension, Ascites, Chronic duration lasting years, Nail clubbing, Weight loss, Anorexia, Dyspnea, Asbestos exposure
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