Mallory-Weiss syndrome
Alerts and Notices
Synopsis

Patients with Mallory-Weiss tears present with hematemesis and/or melena, and often with either epigastric or back pain. Management involves initiation of IV proton pump inhibitors, hemodynamic stabilization (either IV fluids or red blood cell transfusions), and endoscopy, with timing dependent on hemodynamic compromise.
Pediatric Patient Considerations:
While uncommon in the pediatric population, Mallory-Weiss syndrome can occur in children and may indicate an underlying bleeding condition.
Codes
ICD10CM:K22.6 – Gastro-esophageal laceration-hemorrhage syndrome
SNOMEDCT:
35265002 – Mallory-Weiss Syndrome
Look For
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Diagnostic Pearls
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Differential Diagnosis & Pitfalls
- Boerhaave syndrome
- Bleeding esophageal, gastric, or duodenal ulcer
- Gastritis or esophagitis
- Bleeding esophageal varices
- Eosinophilic esophagitis
- Gastric or esophageal cancer
- Epistaxis
- Crohn disease with upper GI tract involvement
- Volvulus (eg, midgut volvulus)
- Malrotation
Best Tests
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Management Pearls
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Therapy
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References
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Last Updated: 05/24/2017