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Mantle cell lymphoma
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Mantle cell lymphoma

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Contributors: Nina Haghi MD, Paritosh Prasad MD
Other Resources UpToDate PubMed

Synopsis

Mantle cell lymphoma (MCL) is a mature B-cell lymphoma that can present with lymphadenopathy, peripheral blood involvement, and/or extranodal involvement. MCL can involve any portion of the gastrointestinal system and may present as lymphomatous intestinal polyposis. It is often a very aggressive disease.

It is characterized by a CCND1 translocation, t(11;14)(q13;q32), in more than 95% of cases.

MCL makes up 3%-10% of non-Hodgkin lymphomas and occurs in older individuals (median age of 60 years) with a male predominance. Patients present with advanced stage (stage III or IV) disease with fever, night sweats, unintentional weight loss, lymphadenopathy, hepatosplenomegaly, and/or abdominal discomfort.

Codes

ICD10CM:
C83.10 – Mantle cell lymphoma, unspecified site

SNOMEDCT:
443487006 – Mantle cell lymphoma

Look For

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

Best Tests

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Management Pearls

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Therapy

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Reviewed: 08/08/2018
Last Updated: 12/19/2018
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Mantle cell lymphoma
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Mantle cell lymphoma : Fatigue, Fever, Hepatomegaly, Night sweats, Abdominal distension, Generalized lymphadenopathy, Leukocytosis, Weight loss, Splenomegaly
Copyright © 2019 VisualDx®. All rights reserved.