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Medulloblastoma in Adult
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Medulloblastoma in Adult

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Contributors: Andrea Wasilewski MD, Jamie Adams MD, Richard L. Barbano MD, PhD
Other Resources UpToDate PubMed

Synopsis

A medulloblastoma is a malignant primary brain tumor located in the posterior fossa near the fourth ventricle. It is the most common malignant brain tumor in children. In adults, the tumor usually presents before age 40.

Initial symptoms may relate to increased intracranial pressure as a consequence of blockage of the fourth ventricle, causing morning headache, nausea / vomiting, and irritability. Later, patients can develop ataxia, frequent falls, papilledema, diplopia, nystagmus, and/or neck stiffness.

This tumor may spread through the cerebrospinal fluid (CSF) to other parts of the brain and spinal cord. It is an aggressive tumor and recurrence is common. Five-year survival rates are about 60% in all age groups. Patients with medulloblastoma are considered higher risk if they present as infants or at an older age, have metastatic disease, and if their tumors have aggressive histopathology or specific molecular markers.

For more information, see OMIM.

Codes

ICD10CM:
C71.6 – Malignant neoplasm of cerebellum

SNOMEDCT:
443333004 – Medulloblastoma

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Last Reviewed: 08/29/2018
Last Updated: 09/07/2018
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Medulloblastoma in Adult
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Medulloblastoma : Altered mental state, Headache, Nausea/vomiting, Ataxia, Diplopia, Gait disturbance, Nystagmus
Imaging Studies image of Medulloblastoma
Axial MRI demonstrating hyperintense medulloblastoma in the posterior fossa in a pediatric patient.
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