Malignant cancer of glandular origin, or resembling glandular secretory properties, which has spread to a distant location outside the site of origin. Common sites are lymph nodes, lungs, liver, and bones. May invade pancreas, breast, small intestine, and prostate. Signs and symptoms include abdominal pain, bone pain, cachexia, diarrhea, dyspnea, hepatomegaly, icterus, regional lymphadenopathy, and vomiting.

Management depends on the extent and location of the metastases. Treatment of specific organ systems should follow treatment guidelines for that organ system, as in the case of prostate or breast cancer. Treatments can include chemotherapy, radiation therapy, and resection.