Minocycline drug-induced pigmentation in Child
The incidence seems highest in patients with conditions such as atopic dermatitis, acne vulgaris, rheumatoid arthritis, pemphigoid, and pemphigus.
Four types of hyperpigmentation have been described: types I–IV. Each type varies in distribution and histology. (For type details, refer to Look For section.)
Note: Children aged younger than 9 years should not be on medications from the tetracycline family of antibiotics.
T50.995A – Adverse effect of other drugs, medicaments and biological substances, initial encounter
110284009 – Drug-induced pigmentation
Differential Diagnosis & Pitfalls
- Drug-induced pigmentation (antimalarials) – brown, gray-brown, blue-black, yellow, or yellow-green pigmentation may occur with use of more than 1 year; may affect the nail beds
- Drug-induced pigmentation, flagellate – bleomycin and other chemotherapy
- Drug-induced pigmentation, amiodarone – initially shows dusky-red erythema with eventual progression to a blue-gray pigmentation of sun-exposed areas
- Post-inflammatory hyperpigmentation has history of preceding inflammation.
- Fixed drug eruption
- Generalized hyperpigmentation is also seen in Addison disease, Cushing syndrome, Wilson disease, chronic renal failure, vitamin B12 deficiency, ochronosis, and Gaucher disease.
- Erythema ab igne
- Ashy dermatosis (erythema dyschromicum perstans)
- Confluent and reticulated papillomatosis (Gougerot-Carteaud syndrome)
- Cutaneous T-cell lymphoma
- Human immunodeficiency virus (HIV)-infected patients and AIDS patients on zidovudine may develop brown macules on the oral mucosa or lips and longitudinal brown bands on nails.
Drug Reaction Data