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Mixed connective tissue disease
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Mixed connective tissue disease

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Contributors: Benjamin L. Mazer MD, MBA, Mary Anne Morgan MD
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Synopsis

An autoimmune overlap syndrome characterized by the presence of symptoms of systemic lupus erythematosus, systemic scleroderma, and polymyositis. Sequential appearance of symptoms make diagnosis challenging, but the basic hallmarks include elevated antinuclear antibodies (ANA), hand / joint findings such as Raynaud phenomenon and swelling, and nonspecific symptoms including fever, fatigue, and myalgias. Mixed connective tissue disease has a wide clinical presentation, from minimally symptomatic to life-threatening cardiac, kidney, or pulmonary involvement.

Codes

ICD10CM:
M35.1 – Other overlap syndromes

SNOMEDCT:
398049005 – Mixed collagen vascular disease

Differential Diagnosis & Pitfalls

Best Tests

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References

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Last Updated: 04/18/2016
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Mixed connective tissue disease
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Mixed connective tissue disease : Fatigue, ANA positive, Leukopenia, Arthralgia, Dyspnea, Anemia, Myalgia, Low grade fever
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