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Mixed essential cryoglobulinemia
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Mixed essential cryoglobulinemia

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Synopsis

Cryoglobulinemia is caused by globulins that undergo reversible precipitation from plasma or serum upon cooling. Type II and Type III cryoglobulins are mixed cryoglobulins that consist of a rheumatoid factor (IgM) complexed with either a monoclonal IgG (Type II) or a polyclonal IgG or non-immunoglobulin serum component (Type III). Mixed cryoglobulins are most commonly associated with hepatitis C and multiple systemic disorders. The organ systems involved include the skin, liver, kidneys, and the musculoskeletal and nervous systems. Lymphadenopathy, hepatomegaly, splenomegaly, arthritis, and arthralgias may be seen.

Codes

ICD10CM:
D89.1 – Cryoglobulinemia

SNOMEDCT:
239947001 – Essential mixed cryoglobulinemia

References

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Last Updated: 10/30/2015
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Mixed essential cryoglobulinemia
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Mixed essential cryoglobulinemia (Clinical Triad) : Palpable purpura, Arthralgia, Asthenia
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