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Monoclonal gammopathy of undetermined significance
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Monoclonal gammopathy of undetermined significance

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Contributors: Carla Casulo MD
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Synopsis

Monoclonal gammopathy of undetermined significance (MGUS) is characterized by the presence of monoclonal protein (M protein) in the blood. M protein is produced by plasma cells in bone marrow. Etiology is unknown. Affected patients may experience peripheral neuropathy and are more likely to experience fractures, osteopenia, or osteoporosis. The condition is typically asymptomatic. MGUS remains benign in 75% of cases, but 25% progress to myeloma or a B-cell disorder (macroglobulinemia, amyloidosis, and lymphoma). Associated conditions include autoimmune disease, chronic viral hepatitis, and certain infections. Affected patients must be monitored regularly since the condition can become malignant.

Codes

ICD10CM:
D47.2 – Monoclonal gammopathy

SNOMEDCT:
35601003 – Monoclonal gammopathy of undetermined significance

Differential Diagnosis & Pitfalls

MGUS should be distinguished from the following:
Many diseases can present with or cause monoclonal gammopathy, including:

Best Tests

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References

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Last Updated: 05/19/2016
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Monoclonal gammopathy of undetermined significance
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Monoclonal gammopathy of undetermined significance : IgA elevated, IgG elevated, No acute distress, Proteinuria, IgM elevated, CRP elevated
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