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Nasopharyngeal cancer
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Nasopharyngeal cancer

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Contributors: Paul C. Bryson MD
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Synopsis

Formation of a malignant epithelial tumor in the nasopharynx. Histopathology includes keratinizing squamous cell carcinoma, differentiated nonkeratinizing carcinoma, undifferentiated nonkeratinizing carcinoma (endemic form), and basaloid squamous cell carcinoma. Common findings include headache, neck or nose mass, epistaxis, nasal obstruction, serous otitis media, tinnitus, otalgia, pharyngitis, and dyspnea.

The condition carries significant mortality, with approximately 50 000 deaths out of 86 000 cases each year worldwide. Rare in the United States and Western Europe, but causes 25% of all cancer-related deaths in Southern China. Also endemic to Southeast Asia, North Africa, and the Arctic. This regional distribution suggests varied etiology and significant risk factors. These include Epstein-Barr virus (EBV) infection, genetic inheritance, smoking, high alcohol consumption, high consumption of preservatives, and rarely, human papillomavirus infection.

Radiation therapy is the mainstay of treatment.

Codes

ICD10CM:
C11.9 – Malignant neoplasm of nasopharynx, unspecified

SNOMEDCT:
187692001 – Malingnant tumor of nasopharynx

Differential Diagnosis & Pitfalls

  • Nasopharyngeal papilloma
  • Nasopharyngeal cyst

Best Tests

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Management Pearls

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References

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Last Updated: 09/22/2017
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Nasopharyngeal cancer
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Nasopharyngeal cancer : Cervical lymphadenopathy, Headache, Hearing loss, Nasal obstruction, Tinnitus, Neck mass, Epistaxis, Trismus
Copyright © 2019 VisualDx®. All rights reserved.