Oral papilloma is also known as squamous papilloma caused by human papillomavirus (HPV). It presents as a slow-growing, cauliflower-like lesion in the oral cavity. Oral papilloma occurs in about 1 of every 250 adults, most often during the third to fifth decades. It also accounts for 8% of oral tumors in children. Virus subtypes 6 and 11 have been identified in 50% of these lesions. The mode of transmission is unknown, but the viruses in this condition appear to have low virulence and infectivity rate. Any oral surface can be affected, but it most commonly appears on the tongue, lips, and soft palate.