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Oral papilloma - Oral Mucosal Lesion
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Oral papilloma - Oral Mucosal Lesion

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Contributors: Carl Allen DDS, MSD, Sook-Bin Woo MS, DMD, MMSc
Other Resources UpToDate PubMed

Synopsis

Oral papilloma is also known as squamous papilloma and is thought to be caused by human papillomavirus (HPV). It occurs in about one of every 250 adults. Virus subtypes 6 and 11 have been identified in 50% of these lesions. The mode of transmission is unknown but the viruses in this condition appear to have low virulence and infectivity rate. There is no sex predilection and it can arise at any age, although most often it is diagnosed in persons 30 to 50 years of age. Any oral surface can be affected but most commonly it appears on the tongue, lips, and soft palate.

Codes

ICD10CM:
D10.30 – Benign neoplasm of unspecified part of mouth

SNOMEDCT:
402908003 – Oral wart

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

  • Verruca vulgaris – Often arises in children where multiple skin lesions, usually affecting the face or fingers, are noted in addition to one or more oral lesions.
  • Condyloma acuminatum – Condyloma is considered a sexually transmitted disease caused by one of several strains of HPV, with lesions developing at the site of sexual contact. They are usually sessile, pink, have blunted projections, are larger than papillomas, and often are multiple.
  • Verruciform xanthoma – An uncommon benign lesion is typically seen on the gingiva or alveolar mucosa and may have a yellowish tinge.
  • Focal epithelial hyperplasia – HPV-related condition that occurs as multiple flattened or rounded papules, typically with the same color as the surrounding mucosa. More common in children, particularly indigenous populations. Focal epithelial hyperplasia-like lesions have also been described in HIV-infected patients.
  • Fibroma

Best Tests

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Therapy

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References

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Last Updated: 09/04/2013
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Oral papilloma - Oral Mucosal Lesion
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Oral papilloma : Dorsal tongue, Gingival-alveolar mucosa, Oral papule, Soft palate/tonsillar
Clinical image of Oral papilloma
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