The most common malignant tumor of bone. It arises from osteoblastic cells. Patients typically present with bone pain or a mass. The long bones are most commonly affected, and the tumor frequently metastasizes to other locations, especially the lung. Osteosarcoma is most common in males under 30 years of age. It can also occur secondary to medical conditions such as Paget disease
and prior radiotherapy. Osteosarcoma is treated with chemotherapy and surgical excision of the primary tumor. With treatment, overall survival is approximately 60%-80%.
C41.9 – Malignant neoplasm of bone and articular cartilage, unspecified
21708004 – Osteosarcoma
Differential Diagnosis & Pitfalls
The differential for the initial presentation of pain is broad and includes stress fracture, arthritis
, and any other painful musculoskeletal conditions.
Upon initial radiography, the lesion of osteosarcoma can still be similar to other primary bone cancers (eg, Ewing sarcoma
), metastatic disease from other primary neoplasms, and noncancerous conditions such as benign tumors, osteomyelitis
, or histiocytosis
Also consider brown tumor, giant cell reparative granuloma, chondroblastoma
, giant cell tumor of bone