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Palmar xanthomas - Skin
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Palmar xanthomas - Skin

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Contributors: Laurie Good MD, Jeffrey D. Bernhard MD, Noah Craft MD, PhD, Lindy P. Fox MD, Lowell A. Goldsmith MD, MPH, Michael D. Tharp MD
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Synopsis

Palmar xanthomas fall under the broader category of plane xanthomas and are yellowish, slightly raised papules specifically found in the palmar creases of the hands. They are found almost exclusively in patients with an underlying familial dysbetalipoproteinemia (FD), an inherited disorder of lipid metabolism, and are often accompanied by tuberous xanthomas in these patients. Nearly 2/3 of patients with FD will have palmar xanthomas. Recognition of the association between palmar xanthomas and FD is critical, as the risk of atherosclerosis and of lipid-related causes of death are severe. As such, interventions are aimed at reducing lipid and cholesterol levels.

Codes

ICD10CM:
E78.2 – Mixed hyperlipidemia

SNOMEDCT:
238953008 – Plane xanthoma

Look For

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

Palmar xanthoma should be considered in the differential for yellow macules / papules of the palms and can be differentiated by other entities on biopsy.

The differential diagnosis would also include:

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Management Pearls

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Therapy

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References

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Last Updated: 12/09/2016
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Palmar xanthomas - Skin
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Palmar xanthomas : Hypercholesterolemia, Palm, Yellow color, Smooth papules, Smooth plaques
Clinical image of Palmar xanthomas
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