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Palmoplantar pustulosis - Skin
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Palmoplantar pustulosis - Skin

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Contributors: Noah Craft MD, PhD, Lindy P. Fox MD, Lowell A. Goldsmith MD, MPH, Michael D. Tharp MD
Other Resources UpToDate PubMed

Synopsis

Palmoplantar pustulosis is a chronic eruption of the palms and soles composed of sterile vesicles and pustules. It is symmetric in distribution, often accompanied by painful fissuring, and is most commonly seen in women aged between 40 and 60. It often resolves spontaneously, and systemic symptoms are usually absent. The pathogenesis is not well understood. It is primarily a diagnosis of exclusion when the clinical exam does not suggest the diagnosis of dermatitis or psoriasis. Risk factors include focal infection, stress, and smoking. Only a minority of patients demonstrate classic plaque psoriasis elsewhere. Associated diseases include thyroid disease, sterile inflammatory bone lesions (part of the SAPHO syndrome: synovitis, acne, pustulosis, hyperostosis, and osteitis), psoriasis, and diabetes mellitus.

Codes

ICD10CM:
L40.3 – Pustulosis palmaris et plantaris

SNOMEDCT:
27520001 – Palmoplantar pustulosis

Look For

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

Best Tests

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Management Pearls

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Therapy

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Updated: 06/04/2013
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Palmoplantar pustulosis - Skin
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Palmoplantar pustulosis : Painful skin lesions, Palms and soles, Pustules
Clinical image of Palmoplantar pustulosis
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