The mechanisms of PTX poisoning include sodium / potassium adenosine triphosphatase (ATPase) channel opening effects that prolong depolarization, causing muscle spasms with myofilament damage and release of muscle enzymes.
Patients typically present within 8-16 hours of ingestion or inhalation exposure with a metallic taste in the mouth, vomiting, abdominal cramps, diarrhea, circumoral and peripheral paresthesias, muscle weakness, seizures, pruritic skin eruptions, chest pain, cough, dyspnea, hypertension, or myoglobinuria.
T65.91XA – Toxic effect of unspecified substance, accidental (unintentional), initial encounter
275385007 – Biological substance poisoning
- Other marine toxins (eg, saxitoxin, brevotoxin, okadaic acid, domoic acid, tetrodotoxin) – Presenting symptoms and the type of seafood the patient was exposed to can help differentiate among the toxins.
- Food poisoning from infectious agents (see gastroenteritis)
- Viral gastroenteritis
- Multiple sclerosis (neurologic symptoms)
- Stroke or transient ischemic attack (TIA)
- Acute inflammatory demyelinating polyneuropathy
- Viral / bacterial conjunctivitis
- Acute pneumonitis
- Reactive airway disease
- Bronchitis (acute or chronic)
- Pneumonia (eg, viral, bacterial)
- Acute respiratory distress syndrome
- Inhalational poisoning (eg, hydrogen fluoride, carbon monoxide, chlorine, hydrogen sulfide)
- Hypersensitivity pneumonitis
- Allergic bronchopulmonary aspergillosis
- Smoke inhalation injury
- Acute coronary syndrome