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Paraneoplastic autonomic neuropathy
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Paraneoplastic autonomic neuropathy

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Contributors: Andrea Wasilewski MD, Jamie Adams MD, Richard L. Barbano MD, PhD
Other Resources UpToDate PubMed

Synopsis

Paraneoplastic autonomic neuropathy is a rare condition where there is sympathetic and/or parasympathetic nervous system dysfunction related to an underlying cancer. Symptoms may begin before or after the diagnosis of cancer and progress over weeks to months. It can occur in many cancers, but small cell lung carcinoma is the most common. Other commonly associated cancers include carcinoma of the thyroid, pancreas, and colon, carcinoid tumors, and Hodgkin lymphoma. It often occurs in conjunction with other paraneoplastic syndromes such as encephalomyelitis.

Signs and symptoms include orthostatic hypotension, constipation, urinary incontinence, erectile dysfunction, dry eyes, and/or dry mouth. There may also be an associated sensory or motor neuropathy. Treatment is focused on treating the underlying malignancy. Prognosis is usually poor, and symptoms often do not improve.

Codes

ICD10CM:
G13.0 – Paraneoplastic neuromyopathy and neuropathy

SNOMEDCT:
77659000 – Paraneoplastic neuropathy

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Differential Diagnosis & Pitfalls

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Therapy

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References

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Last Reviewed: 03/14/2019
Last Updated: 04/29/2019
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Paraneoplastic autonomic neuropathy
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Paraneoplastic autonomic neuropathy : Constipation, Erectile dysfunction, Neuropathy peripheral, Orthostatic hypotension, Urinary incontinence, Dry eyes, Dry mouth
Copyright © 2019 VisualDx®. All rights reserved.