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Parkinson disease
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Parkinson disease

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Contributors: Jamie Adams MD, Richard L. Barbano MD, PhD
Other Resources UpToDate PubMed

Synopsis

Parkinson disease is a neurodegenerative disorder caused by loss of dopaminergic cells. Average age of onset is 60 years, although it can less commonly affect individuals younger than 50 (early- or young-onset Parkinson disease). Cardinal symptoms include rest tremor, rigidity, bradykinesia, and postural and gait instability. Symptoms often start unilaterally, but typically progress to bilateral involvement. Other common signs and symptoms include anosmia, constipation, rapid-eye-movement sleep behavior disorder (RBD), micrographia, decreased finger dexterity, reduced arm swing, masked facies, hypophonia, drooling, dysphagia, cognitive impairment, depression, weight loss, and autonomic dysfunction. "Non-motor" symptoms may also include psychosis (eg, visual hallucinations, delusions). The disease is progressive. Speed of progression is variable among patients, though it is generally slow (years), such that significant changes over less than a years' time should prompt consideration of other diagnoses. 5%-10% of cases have a genetic propensity, often related to autosomal recessive mutations in the Parkin gene.

Related topic: Parkinsonism

Codes

ICD10CM:
G20 – Parkinson's disease

SNOMEDCT:
49049000 – Parkinson's disease

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Differential Diagnosis & Pitfalls

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Therapy

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References

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Last Reviewed: 03/06/2017
Last Updated: 06/12/2018
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Parkinson disease
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Parkinson disease (Parkinson Disease) : Rigidity, Tremor, Bradykinesia, Cognitive impairment, Abnormal gait, Resting tremor
Copyright © 2019 VisualDx®. All rights reserved.