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Peripheral arterial disease
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Peripheral arterial disease

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Contributors: Christine Osborne MD, Ryan Hoefen MD, PhD
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Synopsis

Clinical disorder leading to stenosis or occlusion of the noncardiac vessels, with atherosclerosis as the most common cause in adults over age 40. Risk factors for developing peripheral arterial disease (PAD) include age >70 years, family history, smoking, diabetes, hypertension, hyperlipidemia, and homocysteinemia.

Symptoms develop when the metabolic demand of tissues is greater than the vessels are able to deliver. Most patients with PAD are asymptomatic. In those who develop symptoms, look for extremity pain with activity that is relieved with rest (claudication), limb ischemia with the development of ulcers or gangrenous lesions, or critical acute limb ischemia leading to pallor, pulselessness, paresthesias, and poikilothermia.

Codes

ICD10CM:
I73.9 – Peripheral vascular disease, unspecified

SNOMEDCT:
399957001 – Peripheral arterial occlusive disease

Differential Diagnosis & Pitfalls

Best Tests

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Updated: 03/28/2017
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Peripheral arterial disease
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Peripheral arterial disease : Fatigue, Claudication, Leg pain, Muscle cramp, Leg cramp, Buttock pain
Clinical image of Peripheral arterial disease
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