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Plummer-Vinson syndrome - Oral Mucosal Lesion
See also in: Nail and Distal Digit
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Plummer-Vinson syndrome - Oral Mucosal Lesion

See also in: Nail and Distal Digit
Print Images (3)
Contributors: Carl Allen DDS, MSD, Sook-Bin Woo MS, DMD, MMSc
Other Resources UpToDate PubMed

Synopsis

Plummer-Vinson syndrome is a rare condition, characterized by iron-deficiency anemia, seen in conjunction with glossitis and dysphagia. Improved nutrition is presumably the reason for the decline in reported cases, although certain "fad" diets could play a role currently. Most reported patients have been women between 30 and 50 years of age and of Scandinavian or northern European descent.

Patients typically complain of a burning sensation of the oral mucosa, resulting in intolerance to dentures. Clinical findings include angular cheilitis and marked atrophy of lingual papillae producing a smooth, red appearance. Systemic features include dysphagia due to esophageal webs or strictures, koilonychia and brittle nails. Fatigue, shortness of breath and weakness are characteristic symptoms of the iron-deficiency anemia.

Risk factors include iron-deficiency anemia in women of northern European descent. The process evolves slowly and is progressive unless treated.

Codes

ICD10CM:
D50.1 – Sideropenic dysphagia

SNOMEDCT:
80126007 – Plummer-Vinson syndrome

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

  • Erythematous candidiasis – Candidal glossitis may be caused by broad-spectrum antibiotics ("antibiotic sore mouth") or xerostomia. Culture for Candida albicans is usually positive, but organisms are often sparse on cytologic smears.
  • Atrophic glossitis secondary to deficiency of folic acid, vitamin B12 (pernicious anemia) – The oral findings are similar to iron-deficiency anemia and Plummer-Vinson syndrome. Hematological testing followed by replacement therapy is curative.

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Therapy

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References

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Last Updated: 01/20/2015
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Plummer-Vinson syndrome - Oral Mucosal Lesion
See also in: Nail and Distal Digit
Print 3 Images
View all Images (3)
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Plummer-Vinson syndrome : Atrophic patch tongue, Mouth pain, Dysphagia, Spoon nail, RBC decreased
Clinical image of Plummer-Vinson syndrome
Copyright © 2019 VisualDx®. All rights reserved.