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Pneumocystis jirovecii pneumonia
See also in: Pulmonary
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Pneumocystis jirovecii pneumonia

See also in: Pulmonary
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Contributors: Neil Mendoza MD, Paritosh Prasad MD, Susan Voci MD, Sumanth Rajagopal MD, William Bonnez MD
Other Resources UpToDate PubMed

Synopsis

Pneumocystis jirovecii, formerly known as Pneumocystis carinii, is the causative agent of Pneumocystis pneumonia (PCP), a disease almost exclusively seen in patients with a compromised immune system. Both cell-mediated and humoral immunity are important in control of this infection.

The distribution of the organism is worldwide, and most healthy children are exposed to it within the first 3 years of life, likely due to the inhalation of airborne spores. Some people exposed to P. jirovecii may remain colonized.

Disease manifestations are seen in the setting of immunosuppression.  

Outbreaks of PCP among men who have sex with men heralded the onset of the human immunodeficiency virus (HIV) epidemic. PCP is an AIDS-defining illness and is typically seen in patients infected with HIV with a CD4 cell count of <200/mm3. With improvements in antiretroviral therapy and routine prophylaxis against P. jirovecii in patients infected with HIV and low CD4 cell count, the incidence of infection in this population has decreased, although it remains an important pathogen.

Patients with certain primary immunodeficiencies, including those with severe combined immunodeficiency, are at risk for PCP. Other patients are also at particular risk for PCP due to therapeutic immunosuppression. These include solid organ and autologous and allogenic stem cell transplant recipients. Hospital outbreaks of PCP on solid organ transplantation units have been reported. Patients taking high-dose glucocorticoids (generally considered 20 mg/day for 4 weeks) or other immunosuppressive agents (including tumor necrosis factor-alpha inhibitors) for connective tissue disease, inflammatory bowel disease, or dermatologic conditions are also at increased risk for PCP. Patients undergoing therapy for leukemia or who are receiving T cell-depleting agents or rituximab for other malignancies are also at risk for PCP.

Typical onset in HIV patients is insidious with a fever, dry cough, and progressive shortness of breath with exertion. There may be associated chest pain. Hemoptysis is not typical. Symptoms may progress for weeks or months before patients seek medical care.

The symptoms are typically more acute in onset and more severe in non-HIV-infected patients. These patients may present with respiratory failure.

Physical examination usually reveals fever, tachycardia, and tachypnea. Breath sounds are often normal, but in up to one-third of adults, rales are present. Impaired oxygenation is a common finding, particularly with ambulation, with varying degrees of hypoxemia and elevated alveolar-arterial (A-a) oxygen gradient.

Codes

ICD10CM:
B59 – Pneumocystosis

SNOMEDCT:
79909001 – Pneumocystis carinii

Look For

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

Bacterial pneumonia – particularly in the presence of consolidations
Viral pneumonia – because of the diffuse interstitial pattern
Fungal pneumonia – because of the immunosuppressed status of the patient
Pulmonary tuberculosis – especially with the presence of cavities and calcifications

Noninfectious causes – particularly in the presence of nodules
  • Lung cancer
  • Metastatic disease
  • Post-transplant lymphoproliferative disorder

Best Tests

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Management Pearls

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Therapy

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Updated: 03/29/2017
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Pneumocystis jirovecii pneumonia
See also in: Pulmonary
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Pneumocystis jirovecii pneumonia : Fever, Dyspnea, Dry cough, HR increased, RR increased
Imaging Studies image of Pneumocystis jirovecii pneumonia
Frontal chest x-ray with diffuse, bilateral ground glass opacities with progression to air space consolidation, worse in the lower lobes.
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