Pseudoporphyria in Adult
While commonly associated with NSAIDs, antibiotics, and diuretics with sulfa moieties, pseudoporphyria can also be seen in chronic renal failure (with or without hemodialysis) and with UVA exposure such as tanning beds, PUVA, and excessive natural sun.
E80.20 – Unspecified porphyria
95565000 – Pseudoporphyria
- Porphyria cutanea tarda (PCT) and other porphyrias have associated plasma, stool, and/or urine porphyrin abnormalities. PCT has hypertrichosis, hyperpigmentation, sclerodermoid change, and dystrophic calcification, all of which are rare in pseudoporphyria. Rarely, patients may have increased dermal fibrosis, resulting in skin that resembles the skin of patients with scleroderma, but they do not have associated gastrointestinal or renal abnormalities.
- Variegate porphyria (VP) – May present with skin findings identical to PCT, but patients are also at risk for acute porphyric neurologic crises (not seen in PCT). VP is more common in whites of South African descent and may be differentiated from PCT by the pattern of porphyrins in urine, plasma, and fecal specimens (ratio of urine uroporphyrin to coproporphyrin is approximately 1:1 in VP but up to 8:1 in PCT).
- Hepatoerythropoietic porphyria – Childhood onset with rare autosomal recessive uroporphyrin decarboxylase deficiency.
- Hereditary coproporphyria
- Hydroa vacciniforme
- Bullous lupus erythematosus
- Drug-induced photosensitive reaction
- Epidermolysis bullosa simplex
- Epidermolysis bullosa acquisita
- Acute dermatomyositis
- Polymorphous light eruption
- Contact dermatitis
- Bullous pemphigoid
- Bullous fixed drug eruption
- Bullous arthropod bites