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Quebec platelet disorder
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Quebec platelet disorder

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Synopsis

A partial duplication of PLAU (plasminogen activator urokinase type) in platelets leads to a dominant gain-of-function mutation with delayed bleeding after challenges such as surgery. The increased PLAU levels in platelets increase plasmin generation degradation of alpha-granule proteins. Responds to fibrinolytic inhibitors.

For more information, see OMIM.

Codes

ICD10CM:
D68.2 – Hereditary deficiency of other clotting factors

SNOMEDCT:
128101008 – Platelet factor V deficiency (factor V Quebec)

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Last Updated: 03/29/2017
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Quebec platelet disorder
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Quebec platelet disorder : Bleeding time prolonged, Easy bruising, Fibrinogen decreased, Hemarthrosis, Epistaxis, PLT decreased
Copyright © 2019 VisualDx®. All rights reserved.