Restless legs syndrome (RLS), also known as Willis-Ekbom disease, is a movement disorder characterized by an uncomfortable or distressing urge to move the legs. The sensation occurs during periods of inactivity and is more common at night, although the syndrome can progress to occur during the day. Movement of the legs transiently relieves the uncomfortable sensation.

Symptoms are typically bilateral and rarely involve body parts besides the legs. It can be primary or secondary, with secondary RLS seen in chronic renal failure, iron deficiency, pregnancy, rheumatoid arthritis, and neuropathy. A positive family history is present in up to 60% of cases. Onset of symptoms is typically in middle to old age, but young adults may be affected. Symptoms are typically chronic and may progress, except in secondary RLS where symptoms may improve with treatment of the primary condition.