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Emergency: requires immediate attention
Rhabdomyolysis
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Other Resources UpToDate PubMed
Emergency: requires immediate attention

Rhabdomyolysis

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Contributors: Michael W. Winter MD, Benjamin L. Mazer MD, MBA
Other Resources UpToDate PubMed

Synopsis

Disorder of skeletal muscle breakdown, or necrosis, caused by muscle injury or defects in muscle membrane and myocytes, and characterized by release of myocytic contents into the bloodstream. The classic triad of presenting symptoms consists of weakness, proximal muscle pain, and dark urine; however, more than half of patients do not have muscular complaints. Other signs and symptoms are tenderness, stiffness, impaired mobility, swelling, nausea, elevated enzymes, and electrolyte abnormalities. Life-threatening complications can include myoglobinuria, hyperkalemia, and renal failure.

Management includes monitoring of electrolyte abnormalities, eliminating triggering toxins, and treatment of associated compartment syndrome, when present.

The causes of rhabdomyolysis are many and include alcohol, drugs, infection, toxins, vigorous exercise, severe injury, and acquired or inherited disorders.

Codes

ICD10CM:
M62.82 – Rhabdomyolysis

SNOMEDCT:
89010004 – Rhabdomyolysis

Differential Diagnosis & Pitfalls

Best Tests

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Updated: 07/19/2017
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Emergency: requires immediate attention
Rhabdomyolysis
Print 3 Images
View all Images (3)
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Rhabdomyolysis (Classic Triad) : Dark urine, Muscle weakness, Myoglobinuria, Creatine kinase elevated, Myalgia
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