Stargardt disease is a hereditary disorder of macular degeneration due to mutations in the ABCA4 (autosomal recessive pattern) or ELOVL4 (autosomal dominant pattern) genes. The most common type of juvenile macular degeneration. As a result of the build-up of toxic substances in photoreceptor cells due to ABCA4 mutation, retinal cell death occurs and central vision progressively worsens. Long-chain fatty acid ELOVL4 aggregate build-up impairs cell function and causes retinal cell death, contributing to progressive vision loss. Onset in children ages 7-12. No curative therapy is available, although gene replacement therapy is in development. Avoiding overexposure to light and avoiding vitamin A supplements may help delay progression.