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Stiff person syndrome
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Stiff person syndrome

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Contributors: Jamie Adams MD
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Synopsis

A rare autoimmune or paraneoplastic disorder characterized by fluctuating muscle stiffness and spasms. It can be associated with significantly elevated anti-glutamic acid decarboxylase (GAD) antibodies. Average age of onset is 40-50 years old, but is variable and can even begin in infancy. Patients may present with nonspecific back pain or axial stiffness with or without episodes of severe spasms that resolve over hours to days. Limb muscles and facial muscles may be affected later. Spasms can be precipitated by stress, anxiety, startle, stimulation, or emotion. There can be abdominal contraction as well as significant lumbar lordosis. The disorder is sometimes associated with diabetes, thyroid disease, or pernicious anemia. Prognosis is variable.

For more information, see OMIM.

Codes

ICD10CM:
G25.82 – Stiff-man syndrome

SNOMEDCT:
5217008 – Stiff-man syndrome

Differential Diagnosis & Pitfalls

Best Tests

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References

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Last Updated: 03/29/2017
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Stiff person syndrome
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Stiff person syndrome : Gait disturbance, Leg pain, Muscle spasm, Limb pain, Myalgia, Axial rigidity
Copyright © 2018 VisualDx®. All rights reserved.