Synopsis

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• Responsible for 5% to 20% of cases of pharyngitis in adults.
• Responsible for 15% to 30% of cases of pharyngitis in children.
• Most commonly occurs in children between 5 and 15 years of age.

• Pain or difficulty swallowing
• Fever
• Chills
• Malaise
• Headache – Frequently frontal in location

• Younger children – Abdominal pain, nausea, and vomiting
• Severe unilateral throat pain should raise concern for a peritonsillar or retropharyngeal abscess, especially if this symptom arises or progresses several days after onset of symptoms. Inability to swallow, or odynophagia, should raise concern for a peritonsillar or retropharyngeal abscess.

• Pharyngeal erythema
• Exudate (gray-white), tonsillar pillars or posterior pharynx; occasional palatine petechiae, erythema and edema of the uvula
• Anterior cervical lymphadenopathy (classic angle of jaw)

• Scarlet fever – Usually face sparing, punctate, erythematous, blanchable, sandpaper-like exanthem that may be accentuated in skin folds and creases (Pastia's lines) and may desquamate during convalescence; bright red tongue with inflamed papillae (strawberry tongue); erythematous pharynx and tonsils covered with exudate.
• Children less than 3 years of age – Coryza, purulent nasal discharge, excoriated nares (streptococcosis), and generalized adenopathy.

• Exposure to a person with known streptococcal pharyngitis.
• History of acute rheumatic fever or rheumatic heart disease.

• The incubation period is 24-72 hours.
• In most people, fever resolves within 3-5 days, and throat pain resolves within 1 week, even without specific treatment.
• Patients with untreated GABHS pharyngitis are infectious during the acute phase and for 1 week after.
• Late winter and early spring are peak GABHS seasons.

• Bacteremia
• Cervical lymphadenitis
• Endocarditis
• Fasciitis/myositis
• Mastoiditis
• Meningitis
• Otitis media
• Perianal dermatitis in children
• Peritonsillar/retropharyngeal abscess (quinsy) – Patient has toxic appearance, "hot potato voice," fluctuant peritonsillar mass, and asymmetric deviation of the uvula.
• Pneumonia
• Sinusitis
• Toxic shock

• Post-streptococcal glomerulonephritis – Hematuria and edema with history of a recent streptococcal infection (elevated anti-streptolysin O titer).
• Acute rheumatic fever – Major (carditis, polyarthritis, chorea, erythema marginatum, subcutaneous nodules) and minor (arthralgias, fever, elevated acute-phase reactants, prolonged PR interval).
• Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection.
• Post-streptococcal autoimmune dystonia secondary to striatal necrosis.
• Post-streptococcal reactive arthritis.
• Sydenham's chorea and other autoimmune movement disorders.