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Sweet syndrome - Cellulitis
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Sweet syndrome - Cellulitis

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Contributors: Belinda Tan MD, PhD, Tara Mahar MD, Art Papier MD
Other Resources UpToDate PubMed

Synopsis

Sweet's syndrome, or acute febrile neutrophilic dermatosis, is an inflammatory, neutrophilic disorder of uncertain etiology manifesting as multiple painful erythematous plaques, usually on the extremities. The disease may be seen in patients of all ages, but it is more common in women between the ages of 20 and 60. Sweet's syndrome has been associated with a number of inflammatory, infectious, and malignant diseases, including inflammatory bowel disease, streptococcal pneumonia, rheumatoid arthritis, and hematologic disorders (especially myeloid leukemias and myelodysplastic syndrome). It has also been noted to occur during pregnancy and with the use of certain drugs (sulfamethoxazole-trimethoprim, minocycline, G-CSF).

Sweet's syndrome may have extracutaneous manifestations. Symptoms such as fever, headaches, myalgias, malaise, and arthralgias are frequently present. Fever often precedes the appearance of lesions. The respiratory system is the most common organ system involved, with cough and infiltrates on chest X-ray, but other sites that may be affected include the GI tract, the musculoskeletal system, the kidneys, the heart, and the central nervous system. Conjunctivitis, episcleritis, and oral mucosal lesions have been reported. Sweet's syndrome often responds quite well to systemic corticosteroids, but recurrences are common.

Sweet's syndrome can be differentiated from cellulitis based on associated symptoms and the presence of numerous scattered lesions.

Codes

ICD10CM:
L98.2 – Febrile neutrophilic dermatosis [Sweet]

SNOMEDCT:
84625002 – Sweet's syndrome

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

Best Tests

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Management Pearls

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Therapy

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Updated: 02/12/2015
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Sweet syndrome - Cellulitis
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Sweet syndrome : Fever, Painful skin lesions, CRP elevated, ESR elevated, WBC elevated, Smooth nodules, Smooth plaques
Clinical image of Sweet syndrome
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