The sympatholytic toxidrome is a combination of physical findings that are characteristic of overdose of certain classes of drugs. Beta blockers, calcium-channel blockers, and alpha-2 agonists are associated with this toxidrome.
The primary symptoms of the sympatholytic toxidrome are bradycardia, hypotension, and decreased respiratory rate. Patients may sometimes also present with altered mental status, dry skin, and miosis.
Treatment depends on the particular drug causing the overdose. For example, glucagon and calcium can be given for beta-blocker and calcium-channel blocker overdoses, respectively. IV fluids and vasopressors are frequently used to maintain adequate blood pressure.
Potentially life-threatening emergency
Sympatholytic syndrome
Alerts and Notices
Important News & Links
Synopsis
Codes
ICD10CM:
T44.8X1A – Poisoning by centrally-acting and adrenergic-neuron-blocking agents, accidental (unintentional), initial encounter
SNOMEDCT:
871566007 – Adverse reaction to adrenergic receptor antagonist
T44.8X1A – Poisoning by centrally-acting and adrenergic-neuron-blocking agents, accidental (unintentional), initial encounter
SNOMEDCT:
871566007 – Adverse reaction to adrenergic receptor antagonist
Differential Diagnosis & Pitfalls
To perform a comparison, select diagnoses from the classic differential
Subscription Required
Best Tests
Subscription Required
Drug Reaction Data
Subscription Required
References
Subscription Required
Last Updated:09/07/2023
Potentially life-threatening emergency
Sympatholytic syndrome