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Talc-associated lung disease
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Talc-associated lung disease

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Contributors: Mary Anne Morgan MD
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Synopsis

Can be from industrial exposure or probably more commonly as a result of intravenous administration of talc seen in drug users who inject oral medications containing talc (eg, methadone, pentazocine, amphetamines). Characterized by dry cough, dyspnea, and pulmonary hypertension. Occupational talc exposure is found in the mining, ceramic, rubber, cosmetic, pharmaceutical, paper, textile, plastic, herbicide, and insecticide industries. Most often occurs in men in the fourth to sixth decades of life. Presentation ranges from asymptomatic to fulminant disease. Progressive exertional dyspnea and cough can be the first symptoms. Other early signs and symptoms include weight loss, wheeze on auscultation, night sweats, and recurrent spontaneous pneumothorax. Progressively worsened disease case can present with respiratory failure, pulmonary arterial hypertension, emphysema, or cor pulmonale; however, lab tests may be remarkably normal.

Management includes cessation of exposure to talc and smoking, treatment of pulmonary hypertension with vasodilators, steroids, and lung transplant in late-stage disease. Prognosis is generally poor as condition is found to be progressive and irreversible.

Codes

ICD10CM:
J98.4 – Other disorders of lung

SNOMEDCT:
24417004 – Environmental lung disease

Best Tests

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Updated: 03/03/2016
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Talc-associated lung disease
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Talc-associated lung disease : cocaine, Exertional dyspnea, Dyspnea, Intravenous drug abuse, Dry cough
Copyright © 2019 VisualDx®. All rights reserved.