Recurrent superficial, or migratory, thrombophlebitis (also known as thrombophlebitis migrans or migratory thrombophlebitis, and Trousseau syndrome) usually presents as recurrent episodes of thrombophlebitis that occur simultaneously or successively in disparate locations of the subcutaneous fat over the trunk and lower extremities. Clinically, tender, erythematous cords or nodules are seen. Pathogenically, local thrombosis develops in superficial blood vessels due to a hypercoagulable state.

There is very high association with malignancies including carcinomas, such as adenocarcinomas of the pancreas and lung carcinomas. Armand Trousseau first reported this phenomenon in 1865 when he commented that unexpected thrombophlebitis could indicate an occult visceral malignancy.

These malignancies are often associated with the development of a hypercoagulable state. The exact mechanism for this is not fully elucidated. However, it is postulated that the tumors may secrete procoagulant factors, such as thromboplastin, that can lead to local clotting.

Related topic: Superficial Thrombophlebitis