Thrombotic thrombocytopenic purpura - Skin
The symptoms of TTP are nonspecific and may include fever, fatigue, malaise, arthralgias, altered mental status, seizures, hemiplegia, abdominal pain, nausea, and vomiting. TTP is slightly more common in women, and the average age of onset is approximately 35-40 years.
Thrombocytopenic purpura may also be associated with malignancy, pregnancy, HIV infection, certain medications, and the post-transplantation state. In 2012, multiple cases of TTP-like illness were associated with dissolving and injecting tablets intended for oral administration of a reformulated extended-release form of oxymorphone (Opana ER).
With prompt diagnosis and plasma exchange, the survival rate of TTP has increased from 5%-10% to 80%-90%. When complications occur, they include stroke, arrhythmia, myocardial infarction, hemorrhage, and renal failure, although many survivors suffer no permanent sequelae.
M31.1 – Thrombotic microangiopathy
78129009 – Thrombotic thrombocytopenic purpura
- Hemolytic-uremic syndrome (HUS)
- Idiopathic thrombocytopenic purpura (ITP)
- Disseminated intravascular coagulation (DIC)
- Numerous types of vasculitis, especially those associated with autoimmune and collagen vascular diseases such as systemic lupus erythematosus, scleroderma, and antiphospholipid antibody syndrome
- Post-viral ITP (cytomegalovirus, Epstein-Barr virus, varicella-zoster virus)
- Rocky Mountain spotted fever
- Drug- or radiation-induced aplastic anemia (drugs include heparin, quinine/quinidine, sulfonamides)
- Thrombocytopenia in AIDS patients
- Liver disease
- Disseminated cancer
- Malignant hypertension
- Severe preeclampsia and eclampsia
- Pregnancy-associated thrombocytopenia
- HELLP syndrome (hemolysis, elevated liver function tests, and low platelets) during pregnancy