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Transitional cell carcinoma (urothelial carcinoma)
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Transitional cell carcinoma (urothelial carcinoma)

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Contributors: Carla Casulo MD
Other Resources UpToDate PubMed


Transitional cell carcinoma is a malignant tumor that originates from the cells of the transitional epithelium within the genitourinary tract, usually in the bladder lining. Accounts for 90% of bladder cancer cases. Less frequently arises in the ureter, urethra, or renal pelvis. In rare instances, can involve ovarian or respiratory transitional cells. Subtypes include muscle-invasive, non-muscle-invasive, and metastatic. Tumors are graded based on the amount of cellular differentiation noted on the specimen and range from grade T1-T4; they are classified as low-grade or high-grade. More common in older men, risk factors include smoking and exposure to occupational and industrial chemicals. Characterized by microscopic or gross hematuria and urinary dysfunction. Signs and symptoms include dysuria, urinary frequency, urgency, incontinence, nocturia, flank pain, and bone pain.

Management includes transurethral resection of bladder tumor, chemotherapy, neoadjuvant chemotherapy, radiation therapy, cystectomy, and radical cystectomy.


C65.9 – Malignant neoplasm of unspecified renal pelvis
C66.9 – Malignant neoplasm of unspecified ureter
C67.9 – Malignant neoplasm of bladder, unspecified

27090000 – Transitional cell carcinoma

Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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Last Updated: 04/20/2016
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Transitional cell carcinoma (urothelial carcinoma)
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Transitional cell carcinoma (urothelial carcinoma) : Microscopic hematuria, Urinary frequency, Dysuria, Gross hematuria, Smoker
Imaging Studies image of Transitional cell carcinoma (urothelial carcinoma)
Axial post-contrast MRI demonstrates a rounded, enhancing mass surrounding and obstructing the left ureter. Pathology was consistent with urothelial carcinoma.
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