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Vaccinia-Induced Folliculitis - Smallpox Vaccination
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Vaccinia-Induced Folliculitis - Smallpox Vaccination

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Contributors: Art Papier MD, Vince Fulginiti MD
Other Resources UpToDate PubMed

Synopsis

A benign, transient folliculitis following smallpox vaccination is one of the more frequent vaccination adverse events. A 2003 study of vaccinees at Vanderbilt University confirmed that generalized or focal asymptomatic papules and pustules can appear following vaccination. Multiple reports from vaccination study centers support the relationship of this adverse event to smallpox vaccination.

Patients present with asymptomatic or mildly pruritic lesions of folliculitis 8 to 10 days after vaccination. In all reports during the 2002-2003 vaccination period the lesions spontaneously resolved without scarring.

Codes

ICD10CM:
T88.1XXA – Other complications following immunization, not elsewhere classified, initial encounter

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Differential Diagnosis & Pitfalls

The pustules of folliculitis are smaller and not umbilicated in contrast to the larger umbilicated pustules of generalized vaccinia, accidental implantation, or eczema vaccinatum.
Erythema multiforme minor has target-like plaques (bull's-eyes) or urticarial-appearing plaques.

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Last Updated: 12/04/2013
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Vaccinia-Induced Folliculitis - Smallpox Vaccination
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Vaccinia-Induced Folliculitis : Folliculitis, Individual recently immunized with vaccinia, Primarily truncal, Widespread, Pustules
Clinical image of Vaccinia-Induced Folliculitis
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