ContentsSynopsisCodesLook ForDiagnostic PearlsDifferential Diagnosis & PitfallsBest TestsManagement PearlsTherapyDrug Reaction DataReferences
Vitamin B6 deficiency
Print
Other Resources UpToDate PubMed

Vitamin B6 deficiency

Print Images (1)
Contributors: Abhijeet Waghray MD, Marilyn Augustine MD, Paritosh Prasad MD
Other Resources UpToDate PubMed

Synopsis

Vitamin B6 (pyridoxine) is a water-soluble vitamin absorbed in the jejunum that is present in many foods, including whole grains, vegetables, fish, and meats. Pyridoxine is involved in over 100 different enzyme reactions in the body. These include amino acid metabolism, heme and neurotransmitter synthesis, and the metabolism of glycogen, lipids, and steroids.

Isolated vitamin B6 deficiency is uncommon and usually occurs in conjunction with other vitamin deficiencies. Alcohol use disorder, malabsorption syndromes, or medications (eg, isoniazid, L-dopa, penicillamine, and cycloserine) predispose patients to development of pyridoxine deficiency.

Symptoms are often nonspecific but may include fatigue, glossitis, dermatitis, microcytic anemia, peripheral neuropathy, paresthesia, depression, nausea, and anorexia. Severe vitamin B6 deficiency can result in seizures and personality changes characterized by irritability and confusion.  

In infants, B6 deficiency may lead to diarrhea, seizures (pyridoxine-dependent seizures), and anemia.

Codes

ICD10CM:
E53.1 – Pyridoxine deficiency

SNOMEDCT:
386080007 – Vitamin B6 deficiency

Look For

Subscription Required

Diagnostic Pearls

Subscription Required

Differential Diagnosis & Pitfalls

Best Tests

Subscription Required

Management Pearls

Subscription Required

Therapy

Subscription Required

Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

Subscription Required

References

Subscription Required

Last Updated: 04/19/2018
Copyright © 2019 VisualDx®. All rights reserved.
Vitamin B6 deficiency
Print 1 Images
Vitamin B6 deficiency : Seizures, Delirium, Irritability, Mouth pain, Depression
Copyright © 2019 VisualDx®. All rights reserved.