Lesions usually present as a slow-growing, solitary, well-demarcated, skin-colored to red-brown umbilicated papule or nodule with a crusted, keratotic center. Most are asymptomatic; rarely, patients complain of pruritus or burning, and bleeding, crusting, or drainage may occur. Warty dyskeratomas are located most commonly on sun-exposed areas of the body (scalp, face, and neck). Multiple lesions, lesions involving the oral and vulvar mucosa, and subungual involvement have occasionally been reported.
Warty dyskeratomas are benign. Malignant transformation has not been reported. However, based on 3 reported cases, it has been suggested that there may be an association between the multiple warty dyskeratoma subtype and renal failure.
L85.8 – Other specified epidermal thickening
254676008 – Warty dyskeratoma
- Verruca vulgaris
- Epidermal inclusion cyst
- Seborrheic keratosis
- Hypertrophic actinic keratosis
- Squamous cell carcinoma
- Darier disease – autosomal dominant inherited dermatosis with multiple keratotic papules on the face, trunk, and extremities that worsens in the summertime and after UV exposure
- Transient acantholytic dermatosis (Grover disease) – transient papulovesicular eruption that flares with sun exposure; crops commonly occur on the trunk of elderly men