Xanthoma disseminatum - Skin in Adult
The cause of XD is unknown. It is frequently associated with diabetes insipidus; it may be associated with other conditions (eg, multiple myeloma, Waldenstrom macroglobulinemia, monoclonal gammopathy). The xanthomatous skin lesions tend to form on the flexor surfaces of the arms and legs and in the periocular region. The skin lesions are typically self-limited. Little is known about treatment of XD.
In about half of cases, xanthomatous lesions also occur on mucous membranes including the mouth, pharynx, larynx, conjunctiva, and cornea. Involvement has also been seen in the gastrointestinal tract, respiratory tract, CNS, and optic nerve and can cause significant morbidity and mortality. Osteolytic lesions are rare but have been reported.
E78.2 – Mixed hyperlipidemia
399970005 – Xanthoma disseminatum
- Granuloma annulare
- Lipoid proteinosis
- Molluscum contagiosum
- Hepatic dysfunction
- Systemic malignancy
- Langerhans cell histiocytosis
- Generalized eruptive histiocytosis
- Multicentric reticulohistiocytosis
- Papular xanthoma
- Eruptive xanthoma
- Progressive nodular histiocytosis